Clinical significance of ADAMTS-13/vWF axis in pregnant women at different trimesters of gestation

Introduction. The pandemic of a novel coronavirus infection has demonstrated the importance assessing ADAMTS-13/vWF axis in patients with COVID-19, because decline this ratio mirrors disease severity. However very few data global literature on crosstalk and levels pregnant women remaining contradictory are available. Taking into consideration an impact prevalence thrombosis disorders hemostasis system, investigation issue is highly demanded. Aim: to assess functioning during physiological pregnancy. Materials Methods . A controlled non-randomized study was conducted: main group included 44 physiologically occurring pregnancies at I, II III trimesters; control consisted 45 healthy non-pregnant women. plasma level ADAMTS-13 inhibitor (ADAMTS-13:i), antigen (ADAMTS-13:Ag), vWF (vWF:Ag), activity (ADAMTS-13:Ac) as well relevant (ADAMTS-13:Ac/vWF:Ag) were measured. Results. It shown that parallel increasing gestational age, significant changes occurred ADAMTS-13:Ac/vWF:Ag ratio. In group, trimester found have 0.359 ± 0.121, –0.253 0.741, which significantly differed (p < 0.01) compared (1,134 0,308). Conclusion Our provides new insights ADAMTS-13:/vWF pregnancy trimesters. Decline ADAMTS-13:Ac along vWF:Ag observed age. Apparently, progressive decrease concentration associated its increased consumption due high level. However, small single-center patient cohort, further studies larger-scale needed.